Betaine in Inflammation: Mechanistic Aspects and Applications

Front Immunol. 2018 May 24;9:1070. doi: 10.3389/fimmu.2018.01070. eCollection 2018.

Abstract

Betaine is known as trimethylglycine and is widely distributed in animals, plants, and microorganisms. Betaine is known to function physiologically as an important osmoprotectant and methyl group donor. Accumulating evidence has shown that betaine has anti-inflammatory functions in numerous diseases. Mechanistically, betaine ameliorates sulfur amino acid metabolism against oxidative stress, inhibits nuclear factor-κB activity and NLRP3 inflammasome activation, regulates energy metabolism, and mitigates endoplasmic reticulum stress and apoptosis. Consequently, betaine has beneficial actions in several human diseases, such as obesity, diabetes, cancer, and Alzheimer's disease.

Keywords: betaine; endoplasmic reticulum; inflammation; obesity; oxidative stress.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / chemistry
  • Anti-Inflammatory Agents / pharmacology*
  • Anti-Inflammatory Agents / therapeutic use
  • Betaine / chemistry
  • Betaine / pharmacology*
  • Betaine / therapeutic use
  • Biomarkers
  • Endoplasmic Reticulum Stress / drug effects
  • Energy Metabolism / drug effects
  • Humans
  • Inflammation / drug therapy
  • Inflammation / etiology*
  • Inflammation / metabolism*
  • Oxidation-Reduction / drug effects
  • Oxidative Stress / drug effects
  • Signal Transduction / drug effects
  • Structure-Activity Relationship

Substances

  • Anti-Inflammatory Agents
  • Biomarkers
  • Betaine