Hydroxychloroquine: An old drug with new relevance

Cleve Clin J Med. 2018 Jun;85(6):459-467. doi: 10.3949/ccjm.85a.17034.


Hydroxychloroquine is an immunomodulatory drug that has been used for 60 years to treat malaria and autoimmune diseases such as systemic lupus erythematosus and inflammatory arthritis, and potential new uses and benefits continue to emerge. Toxicity concerns have been addressed with updated prescribing recommendations.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Antirheumatic Agents / pharmacology*
  • Female
  • Humans
  • Hydroxychloroquine / pharmacology*
  • Hyperpigmentation / chemically induced
  • Lupus Erythematosus, Systemic / drug therapy*
  • Muscular Diseases / chemically induced
  • Retinal Diseases / chemically induced


  • Antirheumatic Agents
  • Hydroxychloroquine