Acute kidney injury and mild therapeutic hypothermia in patients after cardiopulmonary resuscitation - a post hoc analysis of a prospective observational trial

Crit Care. 2018 Jun 8;22(1):154. doi: 10.1186/s13054-018-2061-6.


Background: The aim of this study was to investigate the influence of mild therapeutic hypothermia (MTH) on the incidence of and recovery from acute kidney injury (AKI).

Methods: Patients who had undergone successful cardiopulmonary resuscitation (CPR) were included. Serum creatinine and cystatin C were measured at baseline, daily up to 5 days and at ICU discharge. AKI was defined by the Kidney Disease Improving Global Outcomes (KDIGO) criteria. MTH was applied for 24 h targeting a temperature of 33 °C. Neurological outcome was assessed with the Cerebral Performance Categories score at hospital discharge.

Results: 126 patients were included in the study; 73 patients (58%) developed AKI. Patients treated with MTH had a significantly lower incidence of AKI as compared to normothermia (NT) (44 vs. 69%; p = 0.004). Patients with less favourable neurological outcomes had a significantly higher rate of AKI, although when treated with MTH the occurrence of AKI was reduced (50 vs. 80%; p = 0.017). Furthermore, MTH treatment was accompanied by significantly lower creatinine levels on day 0-1 and at ICU discharge (day 0: 1.12 (0.90-1.29) vs. 1.29 (1.00-1.52) mg/dl; p = 0.016) and lower cystatin C levels on day 0-3 and at ICU discharge (day 0: 0.88 (0.77-1.10) vs. 1.29 (1.06-2.16) mg/l; p < 0.001).

Conclusions: Mild therapeutic hypothermia seems to have a protective effect against the development of AKI and on renal recovery. This may be less pronounced in patients with a favourable neurological outcome.

Keywords: Acute kidney injury; Cardiopulmonary resuscitation; Creatinine; Cystatin C; Mild therapeutic hypothermia; Neurological outcome.

Publication types

  • Observational Study

MeSH terms

  • Acute Kidney Injury / epidemiology
  • Acute Kidney Injury / prevention & control*
  • Adult
  • Aged
  • Female
  • Humans
  • Hypothermia, Induced / methods
  • Hypothermia, Induced / standards*
  • Incidence
  • Logistic Models
  • Male
  • Middle Aged
  • Prospective Studies
  • Resuscitation / adverse effects
  • Resuscitation / methods*
  • Resuscitation / statistics & numerical data