The Role of Advanced Glycation End Products in Diabetic Vascular Complications

Sang Youl Rhee; Young Seol Kim

doi:10.4093/dmj.2017.0105

The Role of Advanced Glycation End Products in Diabetic Vascular Complications

Diabetes Metab J. 2018 Jun;42(3):188-195. doi: 10.4093/dmj.2017.0105. Epub 2018 May 31.

Authors

Sang Youl Rhee¹, Young Seol Kim²

Affiliations

¹ Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, Korea.
² Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, Korea. ycell00@gmail.com.

Abstract

In cases of chronic hyperglycemia, advanced glycation end-products (AGEs) are actively produced and accumulated in the circulating blood and various tissues. AGEs also accelerate the expression of receptors for AGEs, and they play an important role in the development of diabetic vascular complications through various mechanisms. Active interventions for glucose and related risk factors may help improve the clinical course of patients by reducing AGEs. This review summarizes recent updates on AGEs that have a significant impact on diabetic vascular complications.

Keywords: Diabetes complications; Glycation end products, advanced; Receptor for advanced glycation end products.

Publication types

Review