Comparative analysis of the human and feline c-sis proto-oncogenes. Identification of 5' human c-sis coding sequences that are not homologous to the transforming gene of simian sarcoma virus

Biochim Biophys Acta. 1985 Jun 24;825(2):140-7. doi: 10.1016/0167-4781(85)90097-1.


Feline and human genetic sequences, homologous to the v-sis gene of simian sarcoma virus, have been isolated from cosmid gene libraries and characterized by restriction endonuclease analysis. Comparison of the two loci revealed their related structural organization. In both loci, similar unique genetic sequences were found upstream of the v-sis homologous region and these hybridized to a 4.2 kbp c-sis transcript in human lung tumor cells. These data establish and map as yet unidentified coding sequences at the 5' part of the c-sis proto-oncogene of both species.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Sequence
  • Cats
  • Cloning, Molecular
  • DNA Restriction Enzymes / metabolism
  • Deoxyribonuclease EcoRI
  • Deoxyribonuclease HindIII
  • Electrophoresis, Agar Gel
  • Humans
  • Nucleic Acid Hybridization
  • Oncogenes*
  • Peptides / genetics*
  • Retroviridae / genetics*
  • Sarcoma Virus, Woolly Monkey / genetics*
  • Transcription, Genetic
  • Transforming Growth Factors


  • Peptides
  • Transforming Growth Factors
  • DNA Restriction Enzymes
  • Deoxyribonuclease EcoRI
  • Deoxyribonuclease HindIII