Toward Precision Medicine for Neurological and Neuropsychiatric Disorders

Rebecca M Gibbs; Scott Lipnick; Joel W Bateman; Lloyd Chen; Henry C Cousins; Elizabeth G Hubbard; Geraldine Jowett; Darren S LaPointe; Maxine J McGredy; Michelle N Odonkor; Giuliana Repetti; Elizabeth Thomas; Lee L Rubin

doi:10.1016/j.stem.2018.05.019

Toward Precision Medicine for Neurological and Neuropsychiatric Disorders

Cell Stem Cell. 2018 Jul 5;23(1):21-24. doi: 10.1016/j.stem.2018.05.019. Epub 2018 Jun 7.

Affiliations

¹ Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
² Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA; Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.
³ Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.
⁴ Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA. Electronic address: lee_rubin@harvard.edu.

PMID: 29887317
DOI: 10.1016/j.stem.2018.05.019

Abstract

The genetic complexity, clinical variability, and inaccessibility of affected tissue in neurodegenerative and neuropsychiatric disorders have largely prevented the development of effective disease-modifying therapeutics. A precision medicine approach that integrates genomics, deep clinical phenotyping, and patient stem cell models may facilitate identification of underlying biological drivers and targeted drug development.

MeSH terms

Humans
Mental Disorders / genetics
Mental Disorders / pathology
Mental Disorders / therapy*
Nervous System Diseases / genetics
Nervous System Diseases / pathology
Nervous System Diseases / therapy*
Precision Medicine*
Stem Cell Transplantation*
Stem Cells / cytology*