Abstract
In utero exposure to immunosuppressive drugs might be a contraindication to rotavirus vaccine, but that may vary according to the immunosuppressive regimen. We evaluated 24 infants born to kidney transplanted mothers exposed to 3 immunosuppressants during pregnancy (prednisone, azathioprine, and tacrolimus or cyclosporine) and 31 control infants not exposed to these medications. No differences in adverse events were detected after rotavirus vaccination at 2 and 4 months.
Keywords:
child; immunosuppressant; pregnancy; rotavirus vaccine; transplant.
© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
MeSH terms
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Case-Control Studies
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Cohort Studies
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Female
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Follow-Up Studies
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Graft Rejection / immunology
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Graft Rejection / prevention & control
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Humans
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Immunization Schedule
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Immunosuppressive Agents / adverse effects*
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Infant
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Kidney Transplantation / adverse effects*
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Maternal Exposure / adverse effects*
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Maternal-Fetal Exchange
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Pregnancy
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Prospective Studies
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Rotavirus Infections / prevention & control*
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Rotavirus Vaccines / administration & dosage*
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Rotavirus Vaccines / adverse effects
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Vaccines, Attenuated / administration & dosage
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Vaccines, Attenuated / adverse effects
Substances
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Immunosuppressive Agents
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RIX4414 vaccine
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Rotavirus Vaccines
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Vaccines, Attenuated