Reconstruction of the genome-scale co-expression network for the Hippo signaling pathway in colorectal cancer

Comput Biol Med. 2018 Aug 1:99:76-84. doi: 10.1016/j.compbiomed.2018.05.023. Epub 2018 May 26.

Abstract

The Hippo signaling pathway (HSP) has been identified as an essential and complex signaling pathway for tumor suppression that coordinates proliferation, differentiation, cell death, cell growth and stemness. In the present study, we conducted a genome-scale co-expression analysis to reconstruct the HSP in colorectal cancer (CRC). Five key modules were detected through network clustering, and a detailed discussion of two modules containing respectively 18 and 13 over and down-regulated members of HSP was provided. Our results suggest new potential regulatory factors in the HSP. The detected modules also suggest novel genes contributing to CRC. Moreover, differential expression analysis confirmed the differential expression pattern of HSP members and new suggested regulatory factors between tumor and normal samples. These findings can further reveal the importance of HSP in CRC.

Keywords: Colorectal cancer; Gene co-expression network; Hippo signaling pathway.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Colorectal Neoplasms* / genetics
  • Colorectal Neoplasms* / metabolism
  • Colorectal Neoplasms* / pathology
  • Gene Expression Regulation, Neoplastic*
  • Gene Regulatory Networks*
  • Genome-Wide Association Study
  • Hippo Signaling Pathway
  • Humans
  • Models, Biological*
  • Neoplasm Proteins* / genetics
  • Neoplasm Proteins* / metabolism
  • Protein Serine-Threonine Kinases* / genetics
  • Protein Serine-Threonine Kinases* / metabolism
  • Signal Transduction*

Substances

  • Neoplasm Proteins
  • Protein Serine-Threonine Kinases