Emerging roles of TRIO and F-actin-binding protein in human diseases

Cell Commun Signal. 2018 Jun 11;16(1):29. doi: 10.1186/s12964-018-0237-y.


TRIO and F-actin-binding protein (TRIOBP) also referred to as Tara, was originally isolated as a cytoskeleton remodeling protein. TRIOBP-1 is important for regulating F-actin filament reorganization. TRIOBP variants are broadly classified as variant-1 or - 4 and do not share exons. TRIOBP variant-5 contains all exons. Earlier studies indicated that TRIOBP-4/5 mutation is a pivotal element of autosomal recessive nonsyndromic hearing loss. However, recent studies provide clues that TRIOBP variants are associated with other human diseases including cancer and brain diseases. In this review, recent functional studies focusing on TRIOBP variants and its possible disease models are described.

Keywords: Actin cytoskeletal organization; Actin-binding protein; Cancer; Hearing loss; TRIOBP; Tara.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Brain / metabolism
  • Disease*
  • Genetic Variation
  • Hearing Loss / metabolism
  • Humans
  • Microfilament Proteins / genetics
  • Microfilament Proteins / metabolism*
  • Neoplasms / metabolism


  • Microfilament Proteins
  • TRIOBP protein, human