Incidence of Macular Holes in the Fellow Eye without Vitreomacular Detachment at Baseline

Ophthalmologica. 2018;240(3):135-142. doi: 10.1159/000488956. Epub 2018 Jun 12.


Purpose: To determine the rate of macular holes (MH) occurring in the fellow eyes of eyes with MH depending on the vitreomacular interface at baseline.

Methods: This was a retrospective study of patients operated on for idiopathic MH, with persistent vitreofoveal attachment in the fellow eye assessed by spectral-domain optical coherence tomography (SD-OCT). Follow-up lasted 6 months or more, and the main outcome was the occurrence of an MH.

Results: The 77 fellow eyes included had a mean follow-up of 34.11 ± 22.3 months (6-78.4). At baseline, 31 eyes had vitreomacular traction (VMT), 35 vitreomacular adhesion, and 11 no posterior vitreous detachment. MH occurred in 19.5% of the cases (15/77). The rate of MH was significantly higher among the eyes with VMT than among the eyes without VMT at baseline (35.5 vs. 8.7%; p = 0.009).

Conclusion: One-third of eyes with VMT at baseline identified by SD-OCT will develop an MH in the following 5 years.

Keywords: Fellow eye; Macular hole; Posterior vitreous detachment; Spectral-domain optical coherence tomography; Vitreomacular adhesion; Vitreomacular traction.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Cell Adhesion
  • Female
  • Humans
  • Incidence
  • Macula Lutea / metabolism
  • Male
  • Middle Aged
  • Retinal Detachment / complications*
  • Retinal Perforations / diagnostic imaging
  • Retinal Perforations / epidemiology*
  • Retinal Perforations / surgery
  • Retrospective Studies
  • Risk Factors
  • Tomography, Optical Coherence
  • Vitreous Body / metabolism
  • Vitreous Detachment / complications*