Antiviral effect of a derivative of isonicotinic acid enisamium iodide (FAV00A) against influenza virus

Acta Virol. 2018;62(2):191-195. doi: 10.4149/av_2018_211.


With only a single class of antiviral drugs existing for treatment of influenza (neuraminidase inhibitors), the search for novel effective compounds is urgently needed. We evaluated a low molecular mass compound, enisamium iodide (FAV00A), against influenza virus infections in primary differentiated normal human bronchial epithelial (NHBE) cells, and in ferrets. FAV00A (500 µg/ml) markedly inhibited influenza virus replication and reduced viral M-gene expression in NHBE cells. Treatment of ferrets with FAV00A (200 mg/kg once daily for 7 days) initiated 24 h after inoculation with 105 TCID50 of influenza A/Wisconsin/67/2005 (H3N2) virus resulted in a significant decrease in virus titers in the upper respiratory tract. Our data show that FAV00A exhibits an antiviral effect against influenza virus in NHBE cells and provides some benefits in a ferret model. Thus, further Keywords: antiviral agents; enisamium iodide; influenza virus; MDCK cells; NHBE cells; ferrets.

MeSH terms

  • Animals
  • Antiviral Agents / chemistry
  • Antiviral Agents / pharmacology*
  • Dogs
  • Ferrets
  • Humans
  • Influenza A Virus, H3N2 Subtype / drug effects*
  • Influenza A Virus, H3N2 Subtype / genetics
  • Influenza A Virus, H3N2 Subtype / physiology
  • Influenza, Human / drug therapy*
  • Influenza, Human / virology
  • Iodides / chemistry*
  • Isonicotinic Acids / chemistry*
  • Madin Darby Canine Kidney Cells
  • Viral Load / drug effects
  • Virus Replication / drug effects


  • Antiviral Agents
  • Iodides
  • Isonicotinic Acids