Research Progress of Bioactive Proteins from the Edible and Medicinal Mushrooms

Curr Protein Pept Sci. 2019;20(3):196-219. doi: 10.2174/1389203719666180613090710.


For centuries, mushrooms have been widely used as traditional Chinese medicine in Asia. Apart from polysaccharides and some small-molecule components, such as flavones, polyphenols and terpenes, mushrooms produce a large number of pharmaceutically active proteins, which have become popular sources of natural antitumor, antimicrobial, immunoenhancing agents. These bioactive proteins include lectins, laccases, Ribosome Inactivating Proteins (RIPs), nucleases, and Fungal Immunomodulatory Proteins (FIPs). The review is to summarize the characterstics of structure and bioactivities involved in antitumor, antiviral, antifungal, antibacterial and immunoenhancing activities of proteins from edible mushrooms, to better understand their mechanisms, and to direct research.

Keywords: Antimicrobial; Asia; antitumor; immunoenhancement; mushroom; protein..

Publication types

  • Review

MeSH terms

  • Agaricales* / chemistry
  • Animals
  • Anti-Infective Agents / chemistry
  • Anti-Infective Agents / metabolism
  • Anti-Infective Agents / pharmacology
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / metabolism
  • Antineoplastic Agents / pharmacology
  • Fungal Proteins* / chemistry
  • Fungal Proteins* / metabolism
  • Fungal Proteins* / pharmacology
  • Humans
  • Phytotherapy


  • Anti-Infective Agents
  • Antineoplastic Agents
  • Fungal Proteins