Familial Pyrimidinemia and Pyrimidinuria Associated With Severe Fluorouracil Toxicity

N Engl J Med. 1985 Jul 25;313(4):245-9. doi: 10.1056/NEJM198507253130407.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Breast Neoplasms / drug therapy
  • Carcinoma, Intraductal, Noninfiltrating / drug therapy
  • Female
  • Fluorouracil / adverse effects*
  • Humans
  • Male
  • Purine-Pyrimidine Metabolism, Inborn Errors / metabolism*
  • Pyrimidines / blood
  • Pyrimidines / metabolism*
  • Pyrimidines / urine
  • Thymine / urine
  • Uracil / urine

Substances

  • Pyrimidines
  • Uracil
  • pyrimidine
  • Thymine
  • Fluorouracil