Fused transcript of abl and bcr genes in chronic myelogenous leukaemia

Nature. 1985 Jun 13-19;315(6020):550-4. doi: 10.1038/315550a0.

Abstract

Human chronic myelogenous leukaemia is characterized by a reciprocal translocation between chromosomes 9 and 22 resulting in an abbreviated form of chromosome 22 and the transfer of the abl cellular oncogene from chromosome 9 into the bcr gene of chromosome 22. Characterization of an 8-kilobase RNA specific to chronic myelogenous leukaemia shows it to be a fused transcript of the two genes. The fused protein that would be produced is probably involved in the malignant process.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Cloning, Molecular*
  • DNA Restriction Enzymes
  • DNA, Neoplasm / genetics
  • Humans
  • Leukemia, Myeloid / genetics*
  • Nucleic Acid Hybridization
  • Oncogenes*
  • Transcription, Genetic*

Substances

  • DNA, Neoplasm
  • DNA Restriction Enzymes