Morphology of Bluetongue Virus-Infected Aedes Albopictus (C6/36) Cell Culture

Prog Clin Biol Res. 1985;178:289-94.


Morphological changes observed in bluetongue virus (BTV)-infected Aedes albopictus (C6/36) suspension cell culture at 28 C were compared to those observed in mammalian stationary cell culture at 37 C. The presence of cytoplasmic macrotubules, viroplasms and progeny virions was confirmed and appears to be the same as seen in mammalian cell culture. In addition progeny virions were observed budding from cell membranes where they appeared to acquire a lipoprotein envelope. Intranuclear macrotubules that are the same diameter as the cytoplasmic macrotubules were also seen. C6/36 cell culture is a model for gaining insight into BTV-replication in the insect host.

MeSH terms

  • Aedes / microbiology*
  • Animals
  • Bluetongue / pathology*
  • Bluetongue virus
  • Cells, Cultured
  • Microscopy, Electron
  • Sheep
  • Virus Replication