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Review
, 51 (8), 373-377

BLT2, a Leukotriene B4 Receptor 2, as a Novel Prognostic Biomarker of Triple-Negative Breast Cancer

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Review

BLT2, a Leukotriene B4 Receptor 2, as a Novel Prognostic Biomarker of Triple-Negative Breast Cancer

JaeIn Park et al. BMB Rep.

Abstract

Triple-negative breast cancer (TNBC) is considered to be a notorious type of cancer due to its aggressive metastatic potential and poor prognosis. Recent evidence suggests that BLT2, a low-affinity LTB4 receptor is critically associated with the phenotypes of TNBC cells, including invasion, metastasis, and survival. Furthermore, in a group of 545 breast cancer patients with metastasis, we observed that the high-BLT2 subgroup had a lower disease-free-survival rate than the low-BLT2 subgroup. Thus, we theorized that anti-BLT2 strategies could facilitate the development of new therapies used for TNBC. This review focuses on recent discoveries regarding BLT2 and its roles in as a novel prognostic biomarker in TNBC. [BMB Reports 2018; 51(8): 373-377].

Conflict of interest statement

CONFLICTS OF INTEREST

The authors have no conflicting interests.

Figures

Fig. 1
Fig. 1
Comprehensive overview of the BLT2 signaling pathways. See text for details.
Fig. 2
Fig. 2
The Kaplan-Meier curves of the overall survival rates of patients with lymph node metastasis stratified by BLT2 expression (n = 545; HR = 1.341; 95% CI = (1.036, 1.735), P = 0.03).
Fig. 3
Fig. 3
Overall survival of breast cancer patients with and without up-regulated BLT2 expression at the mRNA level and a pie chart of the patients’ HER2 status. Absolute patient numbers for each subgroup are indicated.

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