[Antioxidant and anti-inflammatory modulation of exercise during aging]

Rev Esp Geriatr Gerontol. 2018 Sep-Oct;53(5):279-284. doi: 10.1016/j.regg.2018.03.003. Epub 2018 Jun 10.
[Article in Spanish]


Aging is characterised by a gradual loss of the functional reserve. This, along with the fostering of sedentary habits and the increase in risk factors, causes a deterioration of antioxidant defences and an increase of the circulatory levels of inflammatory and oxidative markers, boosting a low-rate chronic inflammation, defined as inflamm-aging. This phenomenon is present in the aetiopathology of chronic diseases, as well as in cognitive deterioration cases associated with aging. The objective of this review is to describe the modulation of antioxidant and anti-inflammatory effects of physical exercise of moderate intensity and volume in the elderly. Evidence of its effectiveness as a non-pharmacological resource is presented, which decreases some deleterious effects of aging. This is mainly due to its neuroprotective action, the increase in circulating anti-inflammatory markers, and the improvement of antioxidant defence derived from its practice.

Keywords: Aging; Cognitive impairments; Deterioro cognitivo; Ejercicio físico; Envejecimiento; Estrés oxidativo; Exercise; Inflamación; Inflammation; Oxidative stress.

Publication types

  • Review

MeSH terms

  • Aged
  • Aging / immunology*
  • Aging / metabolism*
  • Antioxidants / physiology*
  • Exercise / physiology*
  • Humans
  • Inflammation / prevention & control*


  • Antioxidants