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Review
, 8 (6)

History of Glial Cell Line-Derived Neurotrophic Factor (GDNF) and Its Use for Spinal Cord Injury Repair

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Review

History of Glial Cell Line-Derived Neurotrophic Factor (GDNF) and Its Use for Spinal Cord Injury Repair

Melissa J Walker et al. Brain Sci.

Abstract

Following an initial mechanical insult, traumatic spinal cord injury (SCI) induces a secondary wave of injury, resulting in a toxic lesion environment inhibitory to axonal regeneration. This review focuses on the glial cell line-derived neurotrophic factor (GDNF) and its application, in combination with other factors and cell transplantations, for repairing the injured spinal cord. As studies of recent decades strongly suggest that combinational treatment approaches hold the greatest therapeutic potential for the central nervous system (CNS) trauma, future directions of combinational therapies will also be discussed.

Keywords: GFRα-1; Schwann cells; astrogliosis; axonal regeneration; cRET; combinational therapies; glial cell line-derived neurotrophic factor (GDNF); neuroprotection; neurotrauma; spinal cord injury.

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
GDNF family of ligands and receptors. GDNF, Neurturin (NRTN), Artemin (ARTN), and Persephin (PSPN). GFRα 1-4 bind to cRET co-receptors (See Table 1).

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References

    1. Singh A., Tetreault L., Kalsi-Ryan S., Nouri A., Fehlings M.G. Global prevalence and incidence of traumatic spinal cord injury. Clin. Epidemiol. 2014;6:309–331. doi: 10.2147/CLEP.S68889. - DOI - PMC - PubMed
    1. Noble L.J., Wrathall J.R. The blood-spinal cord barrier after injury: Pattern of vascular events proximal and distal to a transection in the rat. Brain Res. 1987;424:177–188. doi: 10.1016/0006-8993(87)91208-X. - DOI - PubMed
    1. Popovich P.G., Horner P.J., Mullin B.B., Stokes B.T. A quantitative spatial analysis of the blood-spinal cord barrier. I. Permeability changes after experimental spinal contusion injury. Exp. Neurol. 1996;142:258–275. doi: 10.1006/exnr.1996.0196. - DOI - PubMed
    1. Schnell L., Fearn S., Klassen H., Schwab M.E., Perry V.H. Acute inflammatory responses to mechanical lesions in the CNS: Differences between brain and spinal cord. Eur. J. Neurosci. 1999;11:3648–3658. doi: 10.1046/j.1460-9568.1999.00792.x. - DOI - PubMed
    1. Schwab M.E., Bartholdi D. Degeneration and regeneration of axons in the lesioned spinal cord. Physiol. Rev. 1996;76:319–370. doi: 10.1152/physrev.1996.76.2.319. - DOI - PubMed
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