[Medicine 4.0, the importance of electronics, information technology and microsystems in modern medicine - the case of customized chemotherapy]

Med Sci (Paris). 2018 May;34(5):456-461. doi: 10.1051/medsci/20183405019. Epub 2018 Jun 13.
[Article in French]


A paradigm shift seems to emerge, not only in industrial engineering ("Industry 4.0") but also in medicine: we are on the threshold to "Medicine 4.0". For many years, molecular biology had a leading position in life sciences, but today scientists start realizing that microelectronic systems, due to an increasing miniaturization, are reaching the scale of human cells and consequently can be used for therapeutic approaches. This article shows how microelectronics can play a major role in modern medicine, through the example of customized chemotherapy. This consists in determining, before the beginning of the treatment, what kind of chemotherapy or drug combination will be most effective for a given patient, and at which dose. This of course allows the lessening of a patient burden during treatment, but also to be more efficient and, in the long run, to save money. In order to do this, we have developed the Intelligent Microplate Reader (IMR), which allows us to accurately test different drugs on living cells by mimicking part of their usual environment.

Publication types

  • Review

MeSH terms

  • Drug Therapy* / methods
  • Drug Therapy* / trends
  • Electronic Health Records / organization & administration
  • Electronic Health Records / supply & distribution
  • Humans
  • Information Science* / methods
  • Information Science* / trends
  • Information Technology* / trends
  • Medicine / methods
  • Medicine / trends*
  • Microtechnology / methods
  • Precision Medicine* / methods
  • Precision Medicine* / trends