FGF binding proteins (FGFBPs): Modulators of FGF signaling in the developing, adult, and stressed nervous system

Biochim Biophys Acta Mol Basis Dis. 2018 Sep;1864(9 Pt B):2983-2991. doi: 10.1016/j.bbadis.2018.06.009. Epub 2018 Jun 12.


Members of the fibroblast growth factor (FGF) family are involved in a variety of cellular processes. In the nervous system, they affect the differentiation and migration of neurons, the formation and maturation of synapses, and the repair of neuronal circuits following insults. Because of the varied yet critical functions of FGF ligands, their availability and activity must be tightly regulated for the nervous system, as well as other tissues, to properly develop and function in adulthood. In this regard, FGF binding proteins (FGFBPs) have emerged as strong candidates for modulating the actions of secreted FGFs in neural and non-neural tissues. Here, we will review the roles of FGFBPs in the peripheral and central nervous systems.

Keywords: Aging; Diseases; FGFBP; Injury; Neuromuscular junction; Synapse.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Carrier Proteins / physiology*
  • Cell Differentiation / physiology
  • Cell Movement / physiology
  • Central Nervous System / cytology
  • Central Nervous System / physiology
  • Fibroblast Growth Factors / metabolism
  • Humans
  • Nervous System Physiological Phenomena*
  • Neurons / cytology
  • Neurons / physiology
  • Peripheral Nervous System / cytology
  • Peripheral Nervous System / physiology
  • Signal Transduction / physiology*
  • Stress, Physiological / physiology*
  • Synapses / physiology


  • Carrier Proteins
  • Fibroblast Growth Factors