Low responsiveness to a hepatitis B virus vaccine in a Chinese population lacks association with ITGAL, CD58, TNFSF15, CCL15, TGFB3, and BCL6 gene variants

Xiaojia Xu; Yulian Li; Yaping Liang; Mingjuan Yin; Yan Zhang; Lingfeng Huang; Zuwei Yu; Jindong Ni

doi:10.1016/j.meegid.2018.06.010

Low responsiveness to a hepatitis B virus vaccine in a Chinese population lacks association with ITGAL, CD58, TNFSF15, CCL15, TGFB3, and BCL6 gene variants

Infect Genet Evol. 2018 Oct:64:126-130. doi: 10.1016/j.meegid.2018.06.010. Epub 2018 Jun 11.

Authors

Xiaojia Xu¹, Yulian Li², Yaping Liang¹, Mingjuan Yin¹, Yan Zhang¹, Lingfeng Huang¹, Zuwei Yu², Jindong Ni³

Affiliations

¹ Department of Environmental and Occupational Health, Dongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Dongguan 523808, China.
² Dalang Community Health Service Centers, Dongguan 523770, China.
³ Department of Environmental and Occupational Health, Dongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Dongguan 523808, China. Electronic address: nijd-gw@gdmu.edu.cn.

PMID: 29902581
DOI: 10.1016/j.meegid.2018.06.010

Abstract

It is known that multiple genetic variants can affect immune responses to the hepatitis B virus (HBV) vaccine. A case-control study was undertaken to examine the possible association of low responsiveness to the HBV vaccine in a Chinese population with genetic polymorphisms in integrin subunit alpha L, CD58, tumor necrosis factor superfamily member 15, C-C motif chemokine ligand 15, transforming growth factor beta 3, and B-cell lymphoma 6 protein. The copy numbers of these six genes were detected in 129 low responders, 129 middle responders and 129 high responders to HBV vaccination. There were no significant differences in the copy numbers of these six genes between the groups. Thus, these findings indicated that the copy number variations of these genes may not be the reason for the low responsiveness to the HBV vaccine in a Chinese population.

Keywords: Copy number variation; Hepatitis B vaccine; Immune response.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Asian People / genetics*
CD58 Antigens / genetics
Chemokines, CC / genetics
Disease Susceptibility
Female
Gene Dosage
Genetic Variation*
Hepatitis B / genetics*
Hepatitis B / immunology*
Hepatitis B / prevention & control
Hepatitis B Vaccines / immunology*
Hepatitis B virus / immunology*
Humans
Macrophage Inflammatory Proteins / genetics
Male
Proto-Oncogene Proteins c-bcl-6 / genetics
Selection, Genetic
Tumor Necrosis Factor Ligand Superfamily Member 15 / genetics

Substances

BCL6 protein, human
CCL15 protein, human
CD58 Antigens
Chemokines, CC
Hepatitis B Vaccines
Macrophage Inflammatory Proteins
Proto-Oncogene Proteins c-bcl-6
TNFSF15 protein, human
Tumor Necrosis Factor Ligand Superfamily Member 15