Chemokines in breast cancer: Regulating metabolism

Darrin Gao; Eleanor N Fish

doi:10.1016/j.cyto.2018.02.010

Chemokines in breast cancer: Regulating metabolism

Cytokine. 2018 Sep:109:57-64. doi: 10.1016/j.cyto.2018.02.010.

Authors

Darrin Gao¹, Eleanor N Fish²

Affiliations

¹ Dept. Immunology, University of Toronto, 1 King's College Circle, Medical Sciences Bldg., Toronto, Ontario M5S 1A8, Canada; Toronto General Hospital Research Institute, University Health Network, 67 College Street, Toronto, Ontario M5G 2M1, Canada. Electronic address: darrin.gao@mail.utoronto.ca.
² Dept. Immunology, University of Toronto, 1 King's College Circle, Medical Sciences Bldg., Toronto, Ontario M5S 1A8, Canada; Toronto General Hospital Research Institute, University Health Network, 67 College Street, Toronto, Ontario M5G 2M1, Canada. Electronic address: en.fish@utoronto.ca.

PMID: 29903574
DOI: 10.1016/j.cyto.2018.02.010

Abstract

Accumulating evidence indicates that chemokine-chemokine receptor interactions invoke biological responses beyond their originally described function of orchestrating leukocyte trafficking. In this review we will extend the findings that chemokines participate actively in the neoplastic process, and consider the contribution of CCL5 activation of CCR5 on breast cancer cells to upregulation of anabolic metabolic events that would support the energy demands of cell replication and proliferation.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Breast Neoplasms / pathology*
Carcinogenesis / pathology*
Cell Proliferation / physiology
Chemokine CCL5 / metabolism*
Female
Humans
Leukocytes / immunology
Lymphocytes, Tumor-Infiltrating / immunology*
Macrophages / immunology
Neoplasm Metastasis / pathology
Neovascularization, Pathologic / pathology
Receptors, CCR5 / metabolism*
T-Lymphocytes, Cytotoxic / immunology*

Substances

CCL5 protein, human
CCR5 protein, human
Chemokine CCL5
Receptors, CCR5