Dynamic hydrogen-bond networks in bacterial protein secretion

FEMS Microbiol Lett. 2018 Jul 1;365(13). doi: 10.1093/femsle/fny124.


The Sec protein secretion machinery includes proteins whose reaction coordinates involve large-scale conformational changes. Dynamic hydrogen-bond networks can provide structural plasticity required by the SecA protein motor and the SecY protein translocon. Here we discuss hydrogen-bond networks of these two Sec proteins from crystal structures and molecular simulations, and the usefulness of molecular simulations approaches to studying dynamic hydrogen bonds and their role in bacterial protein secretion.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Bacteria / chemistry
  • Bacteria / genetics
  • Bacteria / metabolism*
  • Bacterial Proteins / chemistry*
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism*
  • Bacterial Secretion Systems / chemistry*
  • Bacterial Secretion Systems / genetics
  • Bacterial Secretion Systems / metabolism*
  • Hydrogen Bonding
  • Protein Transport


  • Bacterial Proteins
  • Bacterial Secretion Systems