A nutraceutical diet based on Lespedeza spp., Vaccinium macrocarpon and Taraxacum officinale improves spontaneous feline chronic kidney disease

Physiol Rep. 2018 Jun;6(12):e13737. doi: 10.14814/phy2.13737.


Chronic kidney disease is characterized by structural and/or functional impairment of one or both kidneys persisting for more than 3 months. In cats, chronic kidney disease can frequently occur in animals aged over 9 years with an incidence of approximately 10%. Thirty-four client-owned, neutered cats, suffering from stage II-III chronic kidney disease and diagnosed according to the International Renal Interest Society guidelines were randomly assigned to receive either a control diet (n = 17) or a nutraceutical diet (ND; n = 17) for 90 days. Both diets were commercialized for management of CKD symptoms. The diets were identical except that the ND contained tablets that consisted of 60-80% hydrolysed proteins, 20-40% minerals and active substances, that are, Lespedeza spp. 0.0588%, Vaccinium macrocarpom 0.0371%, and Taraxacum officinale 0.0231%. No adverse effects were reported during this study. Both diets resulted in an improvement in CKD symptoms. After a 90-day evaluation, creatinine, blood urea nitrogen, total proteins, and aspartate aminotransferase significantly decreased in cats that received the ND. A significant decrease was also observed in urine turbidity score, color score, and total proteins in cats that received the ND. We have found that a ND based on Lespedeza spp., Vaccinium macrocarpon, and Taraxacum officinale improves key indicators of renal failure in cats affected by chronic kidney disease.

Keywords: Aspartate aminotransferase; blood urea nitrogen; cat; chronic kidney disease; creatinine; feline; total proteins; urine color score; urine turbidity score.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Animals
  • Body Weight
  • Cat Diseases / diet therapy*
  • Cat Diseases / urine
  • Cats
  • Dietary Supplements*
  • Female
  • Lespedeza
  • Male
  • Proteinuria / diet therapy
  • Renal Insufficiency, Chronic / diet therapy*
  • Renal Insufficiency, Chronic / urine
  • Renal Insufficiency, Chronic / veterinary*
  • Taraxacum
  • Treatment Outcome
  • Vaccinium macrocarpon