ZNF341 controls STAT3 expression and thereby immunocompetence

Sci Immunol. 2018 Jun 15;3(24):eaat4941. doi: 10.1126/sciimmunol.aat4941.


Signal transducer and activator of transcription 3 (STAT3) is a central regulator of immune homeostasis. STAT3 levels are strictly controlled, and STAT3 impairment contributes to several diseases including the monogenic autosomal-dominant hyper-immunoglobulin E (IgE) syndrome (AD-HIES). We investigated patients of four consanguineous families with an autosomal-recessive disorder resembling the phenotype of AD-HIES, with symptoms of immunodeficiency, recurrent infections, skeletal abnormalities, and elevated IgE. Patients presented with reduced STAT3 expression and diminished T helper 17 cell numbers, in absence of STAT3 mutations. We identified two distinct homozygous nonsense mutations in ZNF341, which encodes a zinc finger transcription factor. Wild-type ZNF341 bound to and activated the STAT3 promoter, whereas the mutant variants showed impaired transcriptional activation, partly due to nuclear translocation failure. In summary, nonsense mutations in ZNF341 account for the STAT3-like phenotype in four autosomal-recessive kindreds. Thus, ZNF341 is a previously unrecognized regulator of immune homeostasis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Cell Differentiation / genetics
  • Cell Differentiation / immunology
  • Cell Nucleus / metabolism
  • Child
  • Codon, Nonsense
  • Consanguinity
  • Exons / genetics
  • Female
  • Genes, Recessive / genetics
  • Genes, Recessive / immunology
  • Humans
  • Immunocompetence / genetics*
  • Immunoglobulin E / blood
  • Immunoglobulin E / immunology
  • Infant
  • Job Syndrome / blood
  • Job Syndrome / genetics*
  • Job Syndrome / immunology
  • Male
  • Pedigree
  • Promoter Regions, Genetic / genetics
  • STAT3 Transcription Factor / genetics*
  • STAT3 Transcription Factor / immunology
  • Th17 Cells / immunology*
  • Th17 Cells / metabolism
  • Transcription Factors / genetics*
  • Transcription Factors / immunology
  • Transcription Factors / metabolism
  • Young Adult
  • Zinc Fingers / genetics


  • Codon, Nonsense
  • STAT3 Transcription Factor
  • STAT3 protein, human
  • Transcription Factors
  • ZNF341 protein, human
  • Immunoglobulin E