The efficacy of curcumin in managing acute inflammation pain on the post-surgical removal of impacted third molars patients: A randomised controlled trial

J Oral Rehabil. 2018 Sep;45(9):677-683. doi: 10.1111/joor.12679. Epub 2018 Jun 28.


Curcumin is a turmeric-contained active ingredient that has been proven to be effective in treating pain and inflammation due to its analgesic as well as anti-inflammation potential. Odontectomy, on the other hand, has been well known for its post-procedure acute inflammation pain. The aim of the current study was to evaluate the efficacy of curcuminoid in treating acute inflammation post-operative pain in the post-surgical removal of impacted third molars patients. Ninety (44 males; 46 females) participants were recruited in this randomised controlled trial and randomly assigned to the control group (those who consumed mefenamic acid) or the experimental group (those who consumed curcumin). Numeric rating scale (NRS) was used as an evaluation tool to evaluate the intensity of the pain experienced by the participants. Pain evaluation was performed immediately after anaesthesia effect disappeared (T0 ) and an hour after participant took their first (T1 ), second (T2 ) and third (T3 ) course of drugs. All data were collected and analysed using Wilcoxon-Mann-Whitney test. The current study showed that participants in both groups experienced significantly (P < .01) less pain compared to their initial pain level. In addition, when the two groups were compared, it was revealed that those in the treatment group experienced even significantly (P < .01) less pain compared to those in the control group. It can be concluded that curcumin is effective in treating acute inflammation pain in the post-surgical removal of impacted third molars patients.

Keywords: anti-inflammatory; curcumin; inflammation; oro-facial pain; surgical removal of impacted third molars.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Analgesics / therapeutic use
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
  • Curcumin / pharmacology
  • Curcumin / therapeutic use*
  • Female
  • Humans
  • Inflammation / drug therapy*
  • Inflammation / physiopathology
  • Male
  • Middle Aged
  • Molar, Third*
  • Pain, Postoperative / drug therapy*
  • Pain, Postoperative / physiopathology
  • Tooth Extraction / adverse effects*
  • Tooth, Impacted / surgery*
  • Treatment Outcome
  • Young Adult


  • Analgesics
  • Anti-Inflammatory Agents, Non-Steroidal
  • Curcumin