The effects of Melissa officinalis supplementation on depression, anxiety, stress, and sleep disorder in patients with chronic stable angina

Clin Nutr ESPEN. 2018 Aug;26:47-52. doi: 10.1016/j.clnesp.2018.04.015. Epub 2018 May 19.

Abstract

Background: Despite advances in the treatment of cardiovascular diseases in recent decades, patients experience high levels of depression, anxiety, stress, and insomnia. Since the calming effect of Melissa officinalis (MO) has been known, this study aimed to determine the effects of MO supplementation on depression, anxiety, stress, and sleep disturbances in patients with chronic stable angina (CSA).

Methods: In this double-blind placebo-controlled clinical trial, 80 patients with CSA were divided randomly into two groups (taking 3 g MO supplement or placebo daily for 8 weeks). The shortened 21-item version of the depression, anxiety and stress scale (DASS-21) test and Pittsburgh sleep quality index were done before and after the intervention.

Results: At the end of the study, the intervention group receiving MO capsules had a significant reduction in scores of depression, anxiety, stress, and total sleep disturbance, compared with the placebo group (P < 0.05).

Conclusions: The results showed that 8-week supplementation with 3 g MO can decrease depression, anxiety, stress, and sleep disorder in patients with CSA.

Keywords: Anxiety; Chronic stable angina; Depression; Melissa officinalis; Stress.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Angina, Stable / diagnosis
  • Angina, Stable / drug therapy*
  • Angina, Stable / physiopathology
  • Angina, Stable / psychology
  • Anti-Anxiety Agents / adverse effects
  • Anti-Anxiety Agents / isolation & purification
  • Anti-Anxiety Agents / therapeutic use*
  • Antidepressive Agents / adverse effects
  • Antidepressive Agents / isolation & purification
  • Antidepressive Agents / therapeutic use*
  • Anxiety / diagnosis
  • Anxiety / drug therapy*
  • Anxiety / physiopathology
  • Anxiety / psychology
  • Chronic Disease
  • Depression / diagnosis
  • Depression / drug therapy*
  • Depression / physiopathology
  • Depression / psychology
  • Double-Blind Method
  • Female
  • Humans
  • Hypnotics and Sedatives / adverse effects
  • Hypnotics and Sedatives / isolation & purification
  • Hypnotics and Sedatives / therapeutic use*
  • Iran
  • Male
  • Melissa* / chemistry
  • Middle Aged
  • Plant Extracts / adverse effects
  • Plant Extracts / isolation & purification
  • Plant Extracts / therapeutic use*
  • Sleep / drug effects*
  • Sleep Wake Disorders / diagnosis
  • Sleep Wake Disorders / drug therapy*
  • Sleep Wake Disorders / physiopathology
  • Sleep Wake Disorders / psychology
  • Stress, Psychological / diagnosis
  • Stress, Psychological / drug therapy*
  • Stress, Psychological / physiopathology
  • Stress, Psychological / psychology
  • Time Factors
  • Treatment Outcome

Substances

  • Anti-Anxiety Agents
  • Antidepressive Agents
  • Hypnotics and Sedatives
  • Plant Extracts

Associated data

  • IRCT/IRCT2016052928152N1