Use of iontophoresis for the treatment of cancer

J Control Release. 2018 Aug 28:284:144-151. doi: 10.1016/j.jconrel.2018.06.020. Epub 2018 Jun 15.


Despite major advancements in cancer treatments, there are still many limitations to therapy including off-target effects, drug resistance, and control of cancer-related symptoms. There are opportunities for local drug delivery devices to intervene at various stages of cancer to provide curative and palliative benefit. Iontophoretic devices that deliver drugs locally to a region of interest have been adapted for the treatment of cancer. These devices have shown promise in pre-clinical and clinical studies for retinoblastoma, skin, bladder, and pancreatic cancers. Herein, we review iontophoretic devices used in the management of cancer.

Keywords: Cancer; Chemotherapies; Devices; Drug delivery; Iontophoresis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / administration & dosage*
  • Antineoplastic Agents / therapeutic use
  • Drug Delivery Systems / instrumentation*
  • Drug Delivery Systems / methods
  • Equipment Design
  • Humans
  • Iontophoresis / instrumentation*
  • Iontophoresis / methods
  • Neoplasms / drug therapy*
  • Translational Research, Biomedical


  • Antineoplastic Agents