Dynamic interactions between GABAergic and astrocytic networks

Neurosci Lett. 2019 Jan 10;689:14-20. doi: 10.1016/j.neulet.2018.06.026. Epub 2018 Jun 15.

Abstract

Brain network activity derives from the concerted action of different cell populations. Together with interneurons, astrocytes play fundamental roles in shaping the inhibition in brain circuitries and modulating neuronal transmission. In this review, we summarize past and recent findings that reveal in neural networks the importance of the interaction between GABAergic signaling and astrocytes and discuss its physiological and pathological relevance.

Keywords: Astrocytes; Calcium signaling; GABA; Interneurons; Synaptic transmission.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Astrocytes / cytology
  • Astrocytes / metabolism*
  • Astrocytes / pathology
  • Brain Diseases / metabolism
  • Brain Diseases / pathology
  • Calcium Signaling
  • GABAergic Neurons / cytology
  • GABAergic Neurons / metabolism*
  • GABAergic Neurons / pathology
  • Humans
  • Interneurons / cytology
  • Interneurons / metabolism
  • Interneurons / pathology
  • Synaptic Transmission / physiology*