HIV and Aging - Perhaps Not as Dramatic as We Feared?

Gerontology. 2018;64(5):446-456. doi: 10.1159/000489172. Epub 2018 Jun 15.


Ever since the introduction of highly active antiretroviral therapy (ART) in 1995, HIV infection has been linked to "metabolic" complications (insulin resistance, dyslipidemia, osteoporosis, and others). Studies suggested increased rates of myocardial infarction, renal insufficiency, neurocognitive dysfunction, and fractures in HIV-postitive patients. Even long-term suppression of HIV seemed to be accompanied by an excess of deleterious inflammation that could promote these complications. The aims of this viewpoint paper are to summarize recent data and to examine the possibility that the problem of aging-related morbidity in HIV might not be as dramatic as previously believed.

Keywords: Aging; Comedications; Comorbidities; Drug interactions; Frailty; HIV; Polypharmacy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • AIDS Dementia Complex / etiology
  • AIDS-Associated Nephropathy / etiology
  • Adult
  • Aged
  • Aging*
  • Antiretroviral Therapy, Highly Active / adverse effects*
  • Atherosclerosis / complications
  • Atherosclerosis / diagnostic imaging
  • Body Composition
  • Cardiovascular Diseases / complications
  • Drug Interactions
  • Fractures, Bone / complications
  • Frailty / complications
  • HIV Infections / complications*
  • HIV Infections / drug therapy*
  • HIV Infections / mortality
  • Humans
  • Life Expectancy / trends
  • Male
  • Metabolic Diseases / etiology
  • Middle Aged
  • Risk Factors
  • Telomere Homeostasis