Adventures in Atropisomerism: Total Synthesis of a Complex Active Pharmaceutical Ingredient with Two Chirality Axes

Org Lett. 2018 Jul 6;20(13):3736-3740. doi: 10.1021/acs.orglett.8b01218. Epub 2018 Jun 17.

Abstract

A strategy to prepare compounds with multiple chirality axes, which has led to a concise total synthesis of compound 1A with complete stereocontrol, is reported.