Modulation of orbitofrontal-striatal reward activity by dopaminergic functional polymorphisms contributes to a predisposition to alcohol misuse in early adolescence

Psychol Med. 2019 Apr;49(5):801-810. doi: 10.1017/S0033291718001459. Epub 2018 Jun 18.

Abstract

Background: Abnormalities in reward circuit function are considered a core feature of addiction. Yet, it is still largely unknown whether these abnormalities stem from chronic drug use, a genetic predisposition, or both.

Methods: In the present study, we investigated this issue using a large sample of adolescent children by applying structural equation modeling to examine the effects of several dopaminergic polymorphisms of the D1 and D2 receptor type on the reward function of the ventral striatum (VS) and orbital frontal cortex (OFC), and whether this relationship predicted the propensity to engage in early alcohol misuse behaviors at 14 years of age and again at 16 years of age.

Results: The results demonstrated a regional specificity with which the functional polymorphism rs686 of the D1 dopamine receptor (DRD1) gene and Taq1A of the ANKK1 gene influenced medial and lateral OFC activation during reward anticipation, respectively. Importantly, our path model revealed a significant indirect relationship between the rs686 of the DRD1 gene and early onset of alcohol misuse through a medial OFC × VS interaction.

Conclusions: These findings highlight the role of D1 and D2 in adjusting reward-related activations within the mesocorticolimbic circuitry, as well as in the susceptibility to early onset of alcohol misuse.

Keywords: Addiction; adolescence; dopamine D1/D2 receptor; orbital frontal cortex; reward; ventral striatum.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Alcoholism / etiology*
  • Alcoholism / genetics*
  • Alcoholism / metabolism
  • Female
  • Frontal Lobe / diagnostic imaging
  • Frontal Lobe / metabolism*
  • Genetic Predisposition to Disease*
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Polymorphism, Genetic
  • Protein-Serine-Threonine Kinases / genetics
  • Receptors, Dopamine D1 / genetics
  • Receptors, Dopamine D1 / metabolism
  • Receptors, Dopamine D2 / metabolism
  • Reward
  • Ventral Striatum / diagnostic imaging
  • Ventral Striatum / metabolism*

Substances

  • DRD1 protein, human
  • Receptors, Dopamine D1
  • Receptors, Dopamine D2
  • ANKK1 protein, human
  • Protein-Serine-Threonine Kinases