Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Jul 3;28(1):33-44.e3.
doi: 10.1016/j.cmet.2018.05.018. Epub 2018 Jun 14.

Supra-Additive Effects of Combining Fat and Carbohydrate on Food Reward

Affiliations
Free article

Supra-Additive Effects of Combining Fat and Carbohydrate on Food Reward

Alexandra G DiFeliceantonio et al. Cell Metab. .
Free article

Abstract

Post-ingestive signals conveying information about the nutritive properties of food are critical for regulating ingestive behavior. Here, using an auction task concomitant to fMRI scanning, we demonstrate that participants are willing to pay more for fat + carbohydrate compared with equally familiar, liked, and caloric fat or carbohydrate foods and that this potentiated reward is associated with response in areas critical for reward valuation, including the dorsal striatum and mediodorsal thalamus. We also show that individuals are better able to estimate the energy density of fat compared with carbohydrate and fat + carbohydrate foods, an effect associated with functional connectivity between visual (fusiform gyrus) and valuation (ventromedial prefrontal cortex) areas. These results provide the first demonstration that foods high in fat and carbohydrate are, calorie for calorie, valued more than foods containing only fat or carbohydrate and that this effect is associated with greater recruitment of central reward circuits.

Keywords: carbohydrate; dopamine; fMRI; fat; food reward; gut-brain axis; neural circuits; reinforcement; striatum; value.

Similar articles

See all similar articles

Cited by 13 articles

See all "Cited by" articles

LinkOut - more resources

Feedback