Human lens gamma-crystallin sequences are located in the p12-qter region of chromosome 2

Hum Genet. 1985;70(3):217-21. doi: 10.1007/BF00273445.


The human gamma-crystallin genes constitute a multigene family whose members are only expressed in the eye lens. The chromosomal location of these sequences has been determined by screening a panel of human/rodent hybrid cell lines containing overlapping subsets of human chromosomes for the presence of human gamma-crystallin sequences. By correlating these genomic hybridization data with the chromosomal constitution of the somatic cell hybrids, all human gamma-crystallin sequences could be assigned to chromosome 2. The use of human/hamster cell hybrids derived from human Burkitt lymphoma cells carrying a reciprocal translocation between human chromosomes 2 and 8, allowed a further localization of the sequences to the region 2p12-qter.

MeSH terms

  • Animals
  • Base Sequence
  • Burkitt Lymphoma / genetics
  • Cell Line
  • Chromosome Mapping*
  • Chromosomes, Human, 1-3*
  • Cricetinae
  • Crystallins / genetics*
  • DNA / genetics
  • DNA Restriction Enzymes
  • Humans
  • Hybrid Cells
  • Mice
  • Nucleic Acid Hybridization
  • Rats


  • Crystallins
  • DNA
  • DNA Restriction Enzymes