Intervertebral Disc Aging, Degeneration, and Associated Potential Molecular Mechanisms

J Head Neck Spine Surg. 2017;1(4):555569. doi: 10.19080/JHNSS.2017.01.555569. Epub 2017 Nov 16.


Intervertebral disc degeneration is a major cause of neck and back pain, a very common clinical problem. However, no effective treatment is available, which is largely due to the lack of understanding of molecular mechanisms underlying disc degeneration. Here, we briefly described the process of intervertebral disc aging and degeneration and summarized major findings in molecular signaling pathways implicated in disc aging and degeneration.

Keywords: Intervertebral disc degeneration; aging; neck and back pain; senescence.