Radiofrequency radiation emitted from Wi-Fi (2.4 GHz) causes impaired insulin secretion and increased oxidative stress in rat pancreatic islets

Int J Radiat Biol. 2018 Sep;94(9):850-857. doi: 10.1080/09553002.2018.1490039. Epub 2018 Aug 10.


Purpose: There is a great concern regarding the possible adverse effects of electromagnetic radiation (EMR). This study investigated the effects of EMR induced by Wi-Fi (2.45 GHz) on insulin secretion and antioxidant redox systems in the rat pancreas.

Materials and methods: Adult male Sprague-Dawley rats in the weight range of 230-260 g were divided into control, sham, Wi-Fi exposed groups. After long-term exposure (4 h/day for 45 days) to Wi-Fi EMR, plasma levels of glucose and insulin during intraperitoneal glucose tolerance test were measured. Islet insulin secretion and content, lipid peroxidation, and antioxidant status in pancreas of rats were determined.

Results: Our data showed that the weight gain in the WI-FI exposed group was significantly lower than the control group (p < .05). Wi-Fi (2.45 GHz)-exposed group showed hyperglycemia. Plasma insulin level and glucose-stimulated insulin secretion from pancreatic islet were significantly reduced in the Wi-Fi-exposed group. EMR emitted from Wi-Fi caused a significant increase in lipid peroxidation and a significant decrease in GSH level, SOD, and GPx activities of the pancreas.

Conclusions: These data showed that EMR of Wi-Fi leads to hyperglycemia, increased oxidative stress, and impaired insulin secretion in the rat pancreatic islets.

Keywords: Insulin secretion; Wi-Fi; electromagnetic radiation; oxidative stress.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antioxidants / metabolism
  • Blood Glucose / metabolism
  • Body Weight / radiation effects
  • Insulin / blood
  • Insulin Resistance / radiation effects
  • Insulin Secretion / radiation effects*
  • Islets of Langerhans / metabolism*
  • Islets of Langerhans / radiation effects*
  • Lipid Peroxidation / radiation effects
  • Male
  • Organ Size / radiation effects
  • Oxidative Stress / radiation effects*
  • Radio Waves / adverse effects*
  • Rats
  • Rats, Sprague-Dawley
  • Wireless Technology*


  • Antioxidants
  • Blood Glucose
  • Insulin