Resveratrol supplementation decreases blood glucose without changing the circulating CD14 + CD16 + monocytes and inflammatory cytokines in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled study

Nutr Res. 2018 Jun;54:40-51. doi: 10.1016/j.nutres.2018.03.015. Epub 2018 Apr 6.


Chronic low-grade inflammation is the hallmark of type 2 diabetes (T2D). Although in vitro and animal studies have shown that resveratrol exerts anti-inflammatory effects, clinical trials addressing these effects in patients with T2D are limited. Therefore, in the present study, we hypothesized that supplementation of resveratrol might improve inflammatory markers in patients with T2D in a randomized, double-blind, placebo-controlled clinical trial. A total of 45 T2D patients were supplemented with either of 800 mg/d resveratrol or placebo capsules for 8 weeks. Percentage of CD14+CD16+ monocytes, plasma levels of inflammatory cytokines (tumor necrosis factor α, interleukin [IL] 1β, IL-6, and monocyte chemoattractant protein-1), the expression levels of genes involved in the inflammatory responses (toll-like receptor 2, toll-like receptor 4, and nuclear factor κB), lipopolysaccharide-stimulated cytokine (tumor necrosis factor α, IL-1β, and IL-6) secretion from peripheral blood mononuclear cells, and metabolic and anthropometric parameters were assessed at both the baseline level and the end of the study. Compared with the placebo group, we could not detect any significant difference in the percentage of CD14+CD16+ monocytes, lipopolysaccharide-induced cytokine secretion, plasma levels of inflammatory cytokines, and the expression of inflammatory genes in resveratrol group. Moreover, we did not find any significant change in the metabolic and anthropometric parameters except for a significant reduction in fasting blood glucose and blood pressure. In conclusion, 8-week supplementation of resveratrol reduces blood glucose level in patients with T2D without improving their inflammatory markers.

Keywords: CD14(+)CD16(+) monocytes; Clinical trial; Inflammation; PBMC; Resveratrol; Type 2 diabetes.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Antioxidants / pharmacology
  • Biomarkers / blood
  • Blood Glucose / metabolism*
  • Chemokine CCL2 / blood
  • Cytokines / blood*
  • Diabetes Mellitus, Type 2 / blood*
  • Diabetes Mellitus, Type 2 / complications
  • Dietary Supplements
  • Double-Blind Method
  • Female
  • Humans
  • Inflammation / blood*
  • Inflammation / etiology
  • Inflammation Mediators / blood*
  • Interleukins / blood
  • Lipopolysaccharide Receptors
  • Male
  • Middle Aged
  • Monocytes / metabolism*
  • NF-kappa B / blood
  • Plant Extracts / pharmacology
  • Receptors, IgG
  • Resveratrol / pharmacology*
  • Toll-Like Receptors / blood
  • Tumor Necrosis Factor-alpha / blood


  • Antioxidants
  • Biomarkers
  • Blood Glucose
  • Chemokine CCL2
  • Cytokines
  • Inflammation Mediators
  • Interleukins
  • Lipopolysaccharide Receptors
  • NF-kappa B
  • Plant Extracts
  • Receptors, IgG
  • Toll-Like Receptors
  • Tumor Necrosis Factor-alpha
  • Resveratrol