Exposure to hypoglycemia and risk of stroke

Ann N Y Acad Sci. 2018 Nov;1431(1):25-34. doi: 10.1111/nyas.13872. Epub 2018 Jun 19.


In the treatment of both type 1 and type 2 diabetes mellitus, maintaining a euglycemic state represents one of the key challenges. Improper dosing and administration of glucose-lowering drugs is associated with an increased risk of recurrent hypoglycemia episodes. In addition, the risk of adverse cardiovascular events in diabetic patients, particularly myocardial infarctions and strokes, is well established. Current research indicates a potential link between the baseline risk of cardio/cerebrovascular events in diabetic patients and exposure to hypoglycemia. In this review of the literature, we aim to determine if a relationship exists between recurrent hypoglycemia and adverse neurovascular events.

Keywords: cerebrovascular event; diabetes; hypoglycemia; stroke.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Blood Glucose*
  • Diabetes Mellitus / blood
  • Diabetes Mellitus / drug therapy
  • Humans
  • Hypoglycemia / blood
  • Hypoglycemia / complications*
  • Hypoglycemic Agents / adverse effects*
  • Hypoglycemic Agents / therapeutic use
  • Risk Factors
  • Stroke / blood
  • Stroke / etiology*


  • Blood Glucose
  • Hypoglycemic Agents