Two tandemly organized human genes encoding the T-cell gamma constant-region sequences show multiple rearrangement in different T-cell types

Nature. 1985 Aug 1-7;316(6027):464-6. doi: 10.1038/316464a0.


The recent detailed analysis of genes that undergo rearrangement in T cells has shown that the T-cell receptor genes encoding alpha- and beta-chains are involved in specific alterations in T-cell DNA analogous to the immunoglobulin genes. A third type of gene, designated gamma, has been isolated from mouse cytotoxic T lymphocytes, and evidence suggest that the mouse displays very limited diversity in this gene system, having only three variable-region (V) genes and three constant-region (C) genes. The function of the so-called T-cell gamma gene is unknown. We have isolated genomic genes encoding the human homologue of the mouse T-cell gamma gene; as there is no evidence that this T-cell rearranging gene is anything to do with the T3 molecule, we have designated the human T-cell rearranging gene as TRG gamma (ref. 13), to avoid confusion with the T3 gamma-chain, and have shown that the gene locus maps to chromosome 7 in humans. We now report that human DNA contains two tandemly arranged TRG gamma constant-region genes about 16 kilobases apart. These two genes show multiple rearrangement patterns in a variety of T cells, including helper and cytotoxic/suppressor type, as well as in all forms of T-cell leukaemia. Our results indicate variability of this T-cell gene system in man compared with the analogous system in mouse.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Cell Line
  • DNA Restriction Enzymes
  • Genes*
  • Humans
  • Immunoglobulin Constant Regions / genetics*
  • Immunoglobulin Heavy Chains / genetics*
  • Immunoglobulin gamma-Chains / genetics*
  • Immunoglobulins / genetics*
  • Leukemia / immunology
  • Nucleic Acid Hybridization
  • Phenotype
  • T-Lymphocytes / immunology*


  • Immunoglobulin Constant Regions
  • Immunoglobulin Heavy Chains
  • Immunoglobulin gamma-Chains
  • Immunoglobulins
  • DNA Restriction Enzymes

Associated data

  • GENBANK/M13914
  • GENBANK/M13915