5-ASA induces mild acute pancreatitis. Case report and review of the literature

J Gastrointestin Liver Dis. 2018 Jun;27(2):189-194. doi: 10.15403/jgld.2014.1121.272.asa.


5-aminosalicylic acid has been reported to be able of inducing acute pancreatitis as an adverse reaction. However, in most case reports, rechallenge of the drug is missing; therefore, evidence is still needed to confirm its role in the clinical course of acute pancreatitis and its influence on the outcome. Here, we report a case of recurrent acute pancreatitis secondary to 5-aminosalicylic acid, with positive unintentional rechallenge. A systematic search of the literature was performed and 42 cases from 35 articles were summarized concerning the clinical course of 5-aminosalicylic acid induced acute pancreatitis.

Publication types

  • Case Reports
  • Systematic Review

MeSH terms

  • Acute Disease
  • Adult
  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
  • Female
  • Humans
  • Mesalamine / adverse effects*
  • Pancreatitis / chemically induced*
  • Pancreatitis / diagnostic imaging
  • Recurrence
  • Ultrasonography


  • Anti-Inflammatory Agents, Non-Steroidal
  • Mesalamine