Application of pharmacogenetics in clinical practice: problems and solutions

J Neural Transm (Vienna). 2019 Jan;126(1):109-113. doi: 10.1007/s00702-018-1894-0. Epub 2018 Jun 19.

Abstract

This paper discusses difficulties of pharmacogenomic data integration into clinical practice. It emphasizes the need for developing simple and easy to use bioinformatics tools to help prescribers to rapidly access and use genetic data in clinical decision-making at the point of encounter.

Keywords: Clinical informatics tools; Drug–drug interactions; Drug–gene interactions; Medication side effect estimation.

Publication types

  • Review

MeSH terms

  • Clinical Decision-Making*
  • Cytochrome P-450 Enzyme System / genetics*
  • Drug Interactions* / genetics
  • Drug Prescriptions / standards*
  • Drug-Related Side Effects and Adverse Reactions* / enzymology
  • Drug-Related Side Effects and Adverse Reactions* / genetics
  • Humans
  • Pharmacogenomic Testing / standards*
  • Pharmacogenomic Variants*

Substances

  • Cytochrome P-450 Enzyme System