Abnormally reduced primary motor cortex output is related to impaired hand function in chronic stroke

C M Buetefisch; K P Revill; M W Haut; G M Kowalski; M Wischnewski; M Pifer; S R Belagaje; F Nahab; D J Cobia; X Hu; D Drake; G Hobbs

doi:10.1152/jn.00715.2017

Abnormally reduced primary motor cortex output is related to impaired hand function in chronic stroke

J Neurophysiol. 2018 Oct 1;120(4):1680-1694. doi: 10.1152/jn.00715.2017. Epub 2018 Jun 20.

Authors

C M Buetefisch^{1

2}, K P Revill³, M W Haut^{4

5

6}, G M Kowalski¹, M Wischnewski¹, M Pifer⁴, S R Belagaje^{1

7}, F Nahab¹, D J Cobia⁸, X Hu⁹, D Drake¹⁰, G Hobbs¹¹

Affiliations

¹ Department of Neurology, Emory University , Atlanta, Georgia.
² Department of Rehabilitation Medicine, Emory University , Atlanta, Georgia.
³ Department of Psychology, Emory University , Atlanta, Georgia.
⁴ Department of Behavioral Medicine and Psychiatry, West Virginia University School of Medicine , Morgantown, West Virginia.
⁵ Department of Neurology, West Virginia University School of Medicine , Morgantown, West Virginia.
⁶ Department of Radiology, West Virginia University School of Medicine , Morgantown, West Virginia.
⁷ Marcus Stroke and Neuroscience Center, Grady Memorial Hospital , Atlanta, Georgia.
⁸ Department of Psychology and Neuroscience Center, Brigham Young University , Provo, Utah.
⁹ Department of Bioengineering, University of California Riverside , Riverside, California.
¹⁰ Department of Biostatistics, The Mailman School of Public Health, Columbia University , New York, New York.
¹¹ Department of Statistics, West Virginia University , Morgantown, West Virginia.

Abstract

Stroke often involves primary motor cortex (M1) and its corticospinal projections (CST). As hand function is critically dependent on these structures, its recovery is often incomplete. The neuronal substrate supporting affected hand function is not well understood but likely involves reorganized M1 and CST of the lesioned hemisphere (M1_IL and CST_IL). We hypothesized that affected hand function in chronic stroke is related to structural and functional reorganization of M1_IL and CST_IL. We tested 18 patients with chronic ischemic stroke involving M1 or CST. Their hand function was compared with 18 age-matched healthy subjects. M1_IL thickness and CST_IL fractional anisotropy (FA) were determined with MRI and compared with measures of the other hemisphere. Transcranial magnetic stimulation (TMS) was applied to M1_IL to determine its input-output function [stimulus response curve (SRC)]. The plateau of the SRC (MEPmax), inflection point, and slope parameters of the curve were extracted. Results were compared with measures in 12 age-matched healthy controls. MEPmax of M1_IL was significantly smaller ( P = 0.02) in the patients, indicating reduced CST_IL motor output, and was correlated with impaired hand function ( P = 0.02). M1_IL thickness ( P < 0.01) and CST_IL-FA ( P < 0.01) were reduced but did not correlate with hand function. The results indicate that employed M1_IL or CST_IL structural measures do not explain the extent of impairment in hand function once M1 and CST are sufficiently functional for TMS to evoke a motor potential. Instead, impairment of hand function is best explained by the abnormally low output from M1_IL. NEW & NOTEWORTHY Hand function often remains impaired after stroke. While the critical role of the primary motor cortex (M1) and its corticospinal output (CST) for hand function has been described in the nonhuman primate stroke model, their structure and function have not been systematically evaluated for patients after stroke. We report that in chronic stroke patients with injury to M1 and/or CST an abnormally reduced M1 output is related to impaired hand function.

Keywords: human; rehabilitation; stroke.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Evoked Potentials, Motor
Female
Hand / physiopathology*
Humans
Male
Middle Aged
Motor Cortex / physiopathology*
Pyramidal Tracts / physiopathology
Stroke / physiopathology*
Transcranial Magnetic Stimulation

Abstract

Publication types

MeSH terms

Grants and funding