In order to study the significance of CD(276) and CD(133) in the development and progression of colorectal cancer (CRC), the expression of CD(276) and CD(133) was detected by immunohistochemistry in CRC and precancerous lesions. The results showed that the intensity of CD(276) and CD(133) in CRC samples was higher than that in adenoma group and non-adenoma group. CD(276) and CD(133) single and double positive expression were significantly correlated with CRC lymph node metastasis, distant metastasis and survival. CD(276) and CD(133) are significantly correlated to the development and progression of CRC and associated with poor prognosis.
拟探讨CD(276)及CD(133)在结直肠癌（CRC）发生、发展中的作用。采用免疫组化方法检测CD(276)及CD(133)在CRC及癌前病变组织中的表达情况。研究结果显示，CD(276)、CD(133)在CRC组呈高表达，均高于腺瘤组及非腺瘤性息肉组，CD(276)及CD(133)单一表达和双阳性表达均与CRC的淋巴结转移、远处转移及生存相关，提示CD(276)及CD(133)在CRC的发生、发展中起一定作用，且与CRC的不良预后相关。.
Keywords: Adenoma; Antigens, CD(133); Antigens, CD(276); Colorectal neoplasms; Prognosis.