Anti-Inflammatory Effects of Resveratrol: Mechanistic Insights

Int J Mol Sci. 2018 Jun 20;19(6):1812. doi: 10.3390/ijms19061812.


Inflammation is the principal response invoked by the body to address injuries. Despite inflammation constituting a crucial component of tissue repair, it is well known that unchecked or chronic inflammation becomes deleterious, leading to progressive tissue damage. Studies over the past years focused on foods rich in polyphenols with anti-inflammatory and immunomodulatory properties, since inflammation was recognized to play a central role in several diseases. In this review, we discuss the beneficial effects of resveratrol, the most widely investigated polyphenol, on cancer and neurodegenerative, respiratory, metabolic, and cardiovascular diseases. We highlight how resveratrol, despite its unfavorable pharmacokinetics, can modulate the inflammatory pathways underlying those diseases, and we identify future opportunities for the evaluation of its clinical feasibility.

Keywords: chronic diseases; inflammation; resveratrol.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / administration & dosage*
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics*
  • Cardiovascular Diseases / diet therapy
  • Cardiovascular Diseases / drug therapy
  • Clinical Trials as Topic
  • Humans
  • Inflammation / diet therapy
  • Inflammation / drug therapy
  • Mice
  • Neoplasms / diet therapy
  • Neoplasms / drug therapy
  • Obesity / diet therapy
  • Obesity / drug therapy
  • Rats
  • Respiratory Tract Diseases / diet therapy
  • Respiratory Tract Diseases / drug therapy
  • Resveratrol
  • Stilbenes / administration & dosage*
  • Stilbenes / pharmacokinetics*


  • Anti-Inflammatory Agents, Non-Steroidal
  • Stilbenes
  • Resveratrol