IgA Nephropathy Complicated with X-linked Thrombocytopenia

Acta Med Okayama. 2018 Jun;72(3):301-307. doi: 10.18926/AMO/56077.


Renal involvement is occasionally observed in Wiskott-Aldrich syndrome (WAS) and X-linked thrombocytopenia (XLT). It has been reported that galactose-deficient IgA is a closely linked to IgA nephropathy (IgAN), suggesting that patients with XLT/WAS associated with reduced galactosylation on serum IgA are susceptible to IgAN. It is necessary to pay more attention to patients with IgAN due to the potential complication with XLT/WAS. We here present a patient of XLT complicated with mild IgAN who underwent tonsillectomy combined with steroid pulse therapy to achieve complete clinical remission.

Keywords: IgAN nephropathy; Wiskott-Aldrich syndrome; X-linked thrombocytopenia; galactose-deficient IgA1.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Genetic Diseases, X-Linked / complications*
  • Glomerulonephritis, IGA / etiology*
  • Glomerulonephritis, IGA / therapy
  • Humans
  • Male
  • Methylprednisolone / therapeutic use
  • Thrombocytopenia / complications*
  • Tonsillectomy


  • Methylprednisolone

Supplementary concepts

  • Thrombocytopenia 1