Abstract
Two cases of disulfiram-induced hepatitis are presented. Both cases had prompt recurrence of abnormal liver function tests after rechallenge with small doses of the drug. All cases of disulfiram-induced hepatotoxicity reported in the English literature are reviewed.
MeSH terms
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Adult
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Alcoholism / drug therapy
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Alkaline Phosphatase / metabolism
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Chemical and Drug Induced Liver Injury / etiology*
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Cyanamide / therapeutic use
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Disulfiram / adverse effects*
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Drug Hypersensitivity
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Eosinophils
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Female
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Humans
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Liver / drug effects
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Liver / enzymology
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Liver / pathology
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Male
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Peripheral Nervous System Diseases / chemically induced
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Transaminases / metabolism
Substances
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Cyanamide
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Transaminases
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Alkaline Phosphatase
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Disulfiram