Disulfiram-induced hepatitis. Report of two cases and review of the literature

Dig Dis Sci. 1985 Sep;30(9):834-7. doi: 10.1007/BF01309513.

Abstract

Two cases of disulfiram-induced hepatitis are presented. Both cases had prompt recurrence of abnormal liver function tests after rechallenge with small doses of the drug. All cases of disulfiram-induced hepatotoxicity reported in the English literature are reviewed.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Alcoholism / drug therapy
  • Alkaline Phosphatase / metabolism
  • Chemical and Drug Induced Liver Injury / etiology*
  • Cyanamide / therapeutic use
  • Disulfiram / adverse effects*
  • Drug Hypersensitivity
  • Eosinophils
  • Female
  • Humans
  • Liver / drug effects
  • Liver / enzymology
  • Liver / pathology
  • Male
  • Peripheral Nervous System Diseases / chemically induced
  • Transaminases / metabolism

Substances

  • Cyanamide
  • Transaminases
  • Alkaline Phosphatase
  • Disulfiram