PK 11195, an antagonist of peripheral benzodiazepine receptors, reduces ventricular arrhythmias during myocardial ischemia and reperfusion in the dog

Eur J Pharmacol. 1985 Jun 7;112(2):257-60. doi: 10.1016/0014-2999(85)90505-9.

Abstract

PK 11195, an antagonist of peripheral type benzodiazepine receptors, in doses from 5 to 25 mg/kg i.d. protected in a dose-dependent manner dogs against both early and delayed ventricular arrhythmias induced by 20 min ischemia and against ventricular fibrillation following reperfusion. Thus, peripheral-type benzodiazepine receptors might represent a novel target in the treatment of angina and cardiac ischemia.

MeSH terms

  • Animals
  • Anti-Arrhythmia Agents*
  • Blood Pressure / drug effects
  • Coronary Disease / complications
  • Coronary Disease / physiopathology*
  • Dogs
  • Dose-Response Relationship, Drug
  • Female
  • Isoquinolines / pharmacology*
  • Male
  • Receptors, GABA-A / drug effects*

Substances

  • Anti-Arrhythmia Agents
  • Isoquinolines
  • Receptors, GABA-A
  • PK 11195