Griseolic acid, an inhibitor of cyclic adenosine 3',5'-monophosphate phosphodiesterase. II. The structure of griseolic acid

J Antibiot (Tokyo). 1985 Jul;38(7):830-4. doi: 10.7164/antibiotics.38.830.

Abstract

Griseolic acid, a potent inhibitor of cyclic adenosine 3',5'-monophosphate phosphodiesterase, was isolated from the fermentation broth of Streptomyces griseoaurantiacus SANK 63479. Treatment of griseolic acid with HCl-MeOH gave adenine and pseudo-sugar. The structure of griseolic acid, adenine nucleoside type structure, was elucidated by chemical degradation and X-ray analysis, and was shown to be structure 1.

MeSH terms

  • 3',5'-Cyclic-AMP Phosphodiesterases / antagonists & inhibitors*
  • Acetylation
  • Adenosine / analogs & derivatives*
  • Chromatography
  • Crystallography
  • Diazomethane
  • Hydrolysis
  • Magnetic Resonance Spectroscopy
  • Methanol
  • Molecular Conformation

Substances

  • Diazomethane
  • griseolic acid
  • 3',5'-Cyclic-AMP Phosphodiesterases
  • Adenosine
  • Methanol