Crossbridge behaviour during muscle contraction

J Muscle Res Cell Motil. 1985 Apr;6(2):153-61. doi: 10.1007/BF00713057.

Abstract

A number of recent observations by probe and X-ray methods on the behaviour of crossbridges during contraction is considered in relation to the energetics of the process. It is shown that a self-consistent picture of the crossbridge cycle, compatible with these observations and involving strongly and weakly attached crossbridges, can be obtained providing that the tension-generating part of the crossbridge stroke is only about 40 A i.e. about one-third of the usually accepted value. The myosin head subunits in the tension-generating bridges could have a configuration close to that of rigor. A mechanism is suggested whereby rapid tension recovery after quick releases up to 120 A could still be produced by such a system.

Publication types

  • Review

MeSH terms

  • Actins / analysis
  • Actins / physiology
  • Animals
  • Electron Spin Resonance Spectroscopy
  • Fluorescence Polarization
  • Models, Biological
  • Models, Molecular
  • Muscle Contraction*
  • Muscles / analysis*
  • Muscles / physiology
  • Myosins / analysis*
  • Myosins / physiology
  • X-Ray Diffraction

Substances

  • Actins
  • Myosins