Cutaneous and Mucosal Manifestations Associated with Celiac Disease

Nutrients. 2018 Jun 21;10(7):800. doi: 10.3390/nu10070800.


Celiac disease (CD) is an immune-mediated, gluten-induced enteropathy that affects predisposed individuals of all ages. Many patients with CD do not report gastrointestinal symptoms making it difficult to reach an early diagnosis. On the other hand, CD is related to a wide spectrum of extra-intestinal manifestations, with dermatitis herpetiformis (DH) being the best characterized. These associated conditions may be the clue to reaching the diagnosis of CD. Over the last few years, there have been multiple reports of the association between CD and several cutaneous manifestations that may improve with a gluten-free diet (GFD). The presence of some of these skin diseases, even in the absence of gastrointestinal symptoms, should give rise to an appropriate screening method for CD. The aim of this paper is to describe the different cutaneous manifestations that have been associated with CD and the possible mechanisms involved.

Keywords: alopecia areata; atopic dermatitis; celiac disease; cutaneous vasculitis; dermatitis herpetiformis; gluten-free diet; psoriasis; recurrent aphtous ulceration; rosacea; urticaria.

Publication types

  • Review

MeSH terms

  • Alopecia Areata / complications
  • Alopecia Areata / diagnosis
  • Celiac Disease / complications
  • Celiac Disease / diagnosis*
  • Dermatitis Herpetiformis / complications
  • Dermatitis Herpetiformis / diagnosis
  • Dermatitis, Atopic / complications
  • Dermatitis, Atopic / diagnosis
  • Diet, Gluten-Free
  • Gastrointestinal Diseases / complications
  • Gastrointestinal Diseases / diagnosis
  • Glutens / administration & dosage
  • Humans
  • Mucous Membrane / pathology*
  • Psoriasis / complications
  • Psoriasis / diagnosis
  • Rosacea / complications
  • Rosacea / diagnosis
  • Skin / pathology*
  • Skin Diseases / complications
  • Skin Diseases / diagnosis*
  • Stomatitis, Aphthous / complications
  • Stomatitis, Aphthous / diagnosis
  • Urticaria / complications
  • Urticaria / diagnosis
  • Vasculitis, Leukocytoclastic, Cutaneous / complications
  • Vasculitis, Leukocytoclastic, Cutaneous / diagnosis


  • Glutens